If I use the LIBGL_DEBUG=verbose option i get thisĬode: Select all ~/Downloads/Phoenix_Firestorm-Release_i686_4.5 $. ( this is video ram) I would not think that just starting up the app uses a lot of ram. The program itself uses a max of 512 MB of ram while running, hardcoded into the system. Don't know if that has anything to do with the resources the app ran out of. Note also that I'm running Mint without a swap partition because I have 8 gigabytes of ram. Note, I have no clue how to debug a program. Do you think this might work in Mint?Ĭode: Select all libGL error: failed to load driver: r600 I have done so from Vector Linux but they have tools to make this easy. I have never compiled from source from Mint. It was also mentioned that if you compile from source it may work. I know this does work with other 64 bit versions of Mint and the girl in the above thread I mentioned even got it working, so where do I look now? I'm used to all 32 bit apps simply working in a 64 bit os. I missed the above quote in the docs but i'm spoiled. Which it also did for me before I fixed its libraries, just so you know I didn't introduce that I just managed to stop it complaining about its own libraries, but that was not the ultimate solution. If you remove the libraries it complains about from the program's lib folder (as those libraries are installed on your system as well by the ia32-libs-multiarch) at startup it no longer complains about these libraries but crashes with a X Windows System error. This configuration is not currently supported. You will need its 32-bit compatibility environment installed, but If you are running a 64-bit Linux distribution then ![]() * Linux Operating System: A reasonably modern 32-bit Linux environment You can then get a meaningfulīacktrace from your debugger if you break on the gdk_x_error() function.) To debug your program, run it with the -sync command line That is, you will receive the error a while after causing it. (Note to programmers: normally, X errors are reported asynchronously (Details: serial 30 error_code 11 request_code 154 minor_code 3) The error was 'BadAlloc (insufficient resources for operation)'. This probably reflects a bug in the program. The program 'do-not-directly-run-firestorm-bin' received an X Window System error. LibGL error: failed to load driver: swrast LibGL error: Try again with LIBGL_DEBUG=verbose for more details. Tried the recommended command from ~/Downloads/Phoenix_Firestorm-Release_i686_4.5 $ sudo apt-get install ia32-libs ia32-libs-gtk ia32-libs-kde ia32-libs-sdlĬode: Select all libGL error: failed to load driver: i965 $ sudo apt-get install ia32-libs ia32-libs-gtk ia32-libs-kde ia32-libs-sdl Loading shared libraries') may be solved by installing your Linuxĭistribution's 32-bit compatibility packages.įor example, on Ubuntu and other Debian-based Linuxes you might run: 'bin/do-not-directly-run-firestorm-bin: not found' and 'error while Most common problems when launching the Viewer (particularly You are running the Firestorm Viewer on a x86_64 platform. ![]() firestorm: line 152: bin/do-not-directly-run-firestorm-bin: No such file or directoryĮRROR: ld.so: object '/home/dark/Downloads/Phoenix_Firestorm-Release_i686_4.5/lib/libcrypto.so.1.0.0' from LD_PRELOAD cannot be preloaded: ignored.ĮRROR: ld.so: object '/home/dark/Downloads/Phoenix_Firestorm-Release_i686_4.5/lib/libssl.so.1.0.0' from LD_PRELOAD cannot be preloaded: ignored. etc/register_hopprotocol.sh: No such file or directory Running from /home/dark/Downloads/Phoenix_Firestorm-Release_i686_4.5
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![]() Native UI has been retained and the application should behave as it did This approach was eventually changed in versionĢ.0 in order to implement multi-threaded processing, but the existing I felt that this could benefit from the increased flexibility That I prefer to call code natively and not use an external tool to do Anyoneįamiliar with my previous work (MultiPatch for example) might be aware The existing port was a front-end written in AppleScript.I decided to do my own port for two reasons: It also wasn't compatible with Snow Leopard Released, and Bery Rinaldo's port had not been updated in over 3 years I started this port a few weeks before Mac OS X 10.7 Lion was Over time, more features were added as a result of user requests. Of the other features of the program, so they originally were not available The volume of a few tracks I had that were too quiet. This port was made to fulfill one need that I had. Than the Windows front end, so now the express name may imply that it is fast. ![]() However, the addition of multi-threaded processing made the application faster May have made the original intention of the express name no longer necessary. Over time, several missing features were added which ![]() Please do not use it for processing video files. mp4 extension allowed because some AAC files use that extension, but
However, it turns out that Brit isn’t too sure about her new look. ![]() In the caption, she wrote: “Here’s me with purple hair □♀️□♀️□♀️□♀️□□□□ I’m bored, ok ? Very bored so my nail girl said do it !!!!” Posting a video of herself posing in the mirror, Brit has pastel lilac hair. Our range of purple hair dyes are designed for stunning colour that lasts as long as you want it to choose from permanent, semi-permanent and temporary shades. Now Britney is rocking a whole new look – and she looks incredible. Blending the hues will create a metallic finish, giving your hair a shimmer. And to mark her 40 th birthday, Brit rocked big, bouncy curls for her celebratory getaway. Silver and purple are two colors that work well together and are complementary. Then, when the conservatorship finally came to an end, she tried a butter blonde hair colour. ![]() It is ideal for men who love looking fashionable and want to get out of their comfort zone. Short Dark Purple Hair If your skin color is darker, and you have thick bushy black eyebrows, short purple hair is your thing. Britney Spears is finally getting to live her best life.Īlongside travelling with her fiancé Sam Asghari and telling her truth on Instagram, the singer has been trialling different hair looks ever since the end of her conservatorship.įirst, she rocked super sleek straight hair after her father, Jamie Spears, was suspended as the conservator of her estate. Check out these top picked purple hairstyles for men trending this year. ![]() Once players have finished exploring, they can use the Wormhole Generator to get back home.Do you like magic? How about spellcasting? Competing with friends to find out who has mastered more tricks? Or, have you ever found yourself waving a magic wand, only to realize it doesn’t work the way you had hoped?Īn unreal world awaits your Sim in The Sims 4: Realm of Magic is an otherworldly expansion pack for The Sims. There are not, however, any fish on Sixam. Players interested in gardening can find rare flowers and plants on Sixam: the Quill Fruit, Wild Orb, and Fang Flower. There are rare crystals and metals only available on the planet, as well as a six-piece collection of geodes unique to Sixam that will add an environment boost to the Sim's home. Otherwise, players can simply explore the planet and collect rare elements and materials. If the player is traveling for work as a Scientist, they will encounter an alien party held in their honor at the Sixam bar. Once a Sim completes these steps, they can enter the rocket or wormhole and travel to the gorgeous environment on Sixam. These Scientists will need to upgrade their Wormhole Generator with two elements and two uncommon crystals and metals. Players in the Rocket Science branch of the Scientist career can simply add a Wormhole Generator to their rocket, while Scientists in the more general branch of the career will need to build their Wormhole. Choosing the correct options will result in a loading screen, and the Sim will appear in Sylvan Glade. If a player chooses incorrect options, the passage will eject the Sim, and the Sim will be left with an uncomfortable or embarrassed moodlet that will prevent them from trying again until it expires. They should select Follow the Sound, Travel Downstream, Enter the Mist, and Travel to Glade. Players need to enter the passageway and answer a series of roleplay-esque questions about where their Sim will navigate inside the rabbit hole. Eventually, a few more interactions will open up, encouraging players to chat with the tree and compliment its leaves.Īfter Sims spend enough time talking to the tree, the tree will reveal a door. This will be the case the next few times the Sim interacts with the tree.Īfter a while, players will see the option to water the tree, which they should have their Sim do. The only interaction that will be available at first is to View the tree. The player needs to have their Sim approach the tree and click on it. Their Sim has to encourage the tree to reveal its secret door. Players cannot simply access the Grove by finding the tree, however. With patience, finesse, and a few well-placed cheats, players can take their Sims to mystical areas hidden in plain sight within the Sims universe. However, they absolutely should move around and explore to unlock special Sims 4 hidden worlds, which often have empty lots and exclusive collectibles not found elsewhere in the game. Once players choose a neighborhood and lot to move their Sims into, and once the Sims begin to work and live life, players may not move around much or explore the neighborhood. What players might not know, however, is that there are a few hidden locations players can find, both in the base game and in special DLC. Typically, the only way to unlock a new area in The Sims 4 is by purchasing a Game Pack or Expansion Pack. Komorebi Upper Mountain (Snowy Escape Pack) ![]() The new Mozilla VPN can be used on a maximum of five devices and is compatible with Windows OS, Google Android, Chromebooks, and Apple iOS at the moment. If you are interested to learn more about the product, the Beta VPN is available for download in the US now. However, with work introductory hints that that Mozilla will raise the price in the future and the current rate is a limited time offer.Īs we realize our vision to provide next-generation privacy and security solutions, we would like to invite you to continue to share your thoughts with us, follow our journey through this blog, and stay connected via the waitlist here *. ![]() Initially, Mozilla VPN will be launched in the US at an introductory price of $4.99/month. The new product comes with stringent privacy protections including a no-logging policy and offers system-wide protection while the extension only offered protected within Firefox. Such as Mozilla VPN is based on the Swedish Mullvad and uses WireGuard whereas the previous version was Cloudfare-based. Mozilla VPN is different from Firefox Private Networks VPN in many ways. See: Best legal & free online streaming sites for movies & TV shows 2020 Mozilla has announced to release its highly anticipated virtual private network (VPN) service in the “next few weeks.” The product’s beta version was launched in the USA in 2019 as Firefox Private Networks VPN, and it has now been rebranded as Mozilla VPN to expand its scope to a wider audience.Īlso, the company has expanded the product’s scope from an extension to a full-device VPN having the capability of routing traffic for the operating system including other browsers. A Firefox account – used primarily for syncing copies of the browser on multiple devices – as is a credit card.Much-Awaited Mozilla VPN will be available within weeks. Users can register with Mozilla VPN here. "In a world where unpredictability has become the 'new normal,' we know that it's more important than ever for you to feel safe, and for you to know that what you do online is your own business," Mozilla said in a July 15 post to its main blog. Mozilla did hint at the endemic chaos of 2020, though. Instead, the firm ticked off general security and privacy reasons for using VPN, including broad-based anonymity and encryption when using public Wi-Fi, such as that in classrooms and coffee shops. Mozilla made its case for VPN without citing the above. Workers would have been long equipped with VPN, almost certainly by their employer. It's unlikely that Mozilla VPN will benefit from that work-at-home requirement. climbed by over 120% between March 8 and March 22, for instance. In most cases, those people needed a VPN to remotely access organization data, ensuring that the transmissions back and forth between home and office or agency servers was secure. VPN usage exploded in March when the coronavirus pandemic forced businesses and governments to shutter, then send employees home to work from there. Mozilla VPN will use the WireGuard open-source protocol – it promises better performance and less power consumption than rival standards. Mullvad's policies appear to be a good fit with Mozilla's overarching attention to privacy: Mullvad logs "nothing whatsoever that can be connected to" an account, which is labeled with a number rather than a user name. ![]() (The supplier of Mozilla's VPN servers, Swedish-company Mullvad, sells VPN service for the flat rate of €5 per month, the equivalent of $5.72 a month at the moment.)Īlthough Firefox Private Network utilized Cloudflare's proxy servers, Mozilla switched to Mullvad, an open-source creator and maintainer of a global network of proxy servers. It's not clear what portion, if any, of the fees for Mozilla VPN will be retained by the browser maker. The Firefox Private Network was seen as the first of the paid services Mozilla would eventually introduce – another might be online storage – in an attempt to create new revenue streams to augment what the organization is paid to make specific search engines the Firefox default. Mozilla kicked off a VPN preview – then tagged Firefox Private Network – nearly a year ago that relied on a browser extension and was free to users within the U.S. For the monthly fee, users can access the VPN from up to five devices. The service will be offered on macOS and Linux devices "soon," while the iOS version is currently in beta, Mozilla said. ![]() Besides the U.S., Canada and the U.K., Mozilla VPN is also available in Singapore, Malaysia and New Zealand. and three other countries, part of its strategy to expand revenue opportunities for its Firefox browser.ĭubbed Mozilla VPN, the service costs $4.99 per month and is available for devices running Windows and Android. Mozilla last week launched its virtual private network (VPN) in the U.S., Canada, the U.K. ![]() The song, written during a quarantine jam session, is a big production number complete with horns, synths, detailed harmonies and an acoustic intermission.Ĭlark (who took the name St. The track sounds more like a U2 song than a dance anthem, but with Bono's vocals and The Edge's reverb-heavy guitar backed by widescreen electronics and soaring strings, they couldn't be accused of parking the bus.Īnd Crowded House gear up for next month's Dreamers Are Waiting, their first new album in 11 years, with new single Playing With Fire. Like a team a goal down in extra time, the trio throw everything into the mix. With only four weeks until the rescheduled Euro 2020 football tournament kicks off in Rome, the season of soccer singles is upon us.įirst out of the dressing room is the unlikely strike partnership of Bono and The Edge, of U2, and Dutch DJ Martin Garrix, who today release the event's official single We Are The People. The season of soccer singles ahead of the Euro 2020 has brought the unlikely partnership of Bono and The Edge, of U2, and Dutch DJ Martin Garrix (all pictured) Moving away from the electronic rock of 2017's Masseduction, Texas-raised Clark shuns complex arrangements in favour of soft vocal harmonies and woozy retro-pop in the style of Lana Del Rey. Vincent - and Daddy's Home is all the better for it. Singer-songwriter Annie Clark streamlines her approach on her sixth album as St. Cosmic Fringes finds Weller imitating Blur - ironic considering his influence on Britpop.īut with composer Hannah Peel adding sumptuous strings, there's plenty to admire in an album that's short, sharp and low on filler. ![]() There are cameos from Weller's daughter Leah and young Liverpudlian singer and guitarist Lia Metcalfe. The kitchen sink drama Failed harks back to Weller's years fronting The Jam.Ī string of special guests are well chosen, maintaining Weller's habit of working with both older and younger musicians.Īndy Fairweather Low, of 1960s band Amen Corner, is a powerful presence on the soulful Testify. Glad Times, a yearning soul ballad on a par with The Style Council's You're The Best Thing, is steeped in lockdown melancholy. The correct order is shown below.The Black Keys' singer Dan Auerbach (pictured on April 17) and drummer Pat Carney have long looked to the blues, but they've rarely sounded as raw as on covers album Delta Kream The original album cover has a printing mistake which shows tracks 4 & 5 in the wrong order. Critical reception Įxclaim! wrote: "Infuriatingly, relentlessly dull, suggests that Weller is not only dry of opinions and melodies, but disengaged from the very concept of fresh ideas." The Guardian called the album "a mustering of forces, as if 's suddenly realised that coasting on his reputation as Mr Authentically Gritty won't keep those automatic Brit awards coming in." The New Zealand Herald called it "a solid, often dense, and musicianly collection that in its acoustic-framed songs echoes Wildwood." Track listing The string arrangements were contributed by Robert Kirby. Its name was inspired by the Helios desk used in the recording studio. Heliocentric was produced by Brendan Lynch.
![]() Katt Williams tour is produced by North American Entertainment Group Inc., one of the leading independent promoters of entertainment tours and live events in the United States. Celebrated for his brilliance and ingenuity on stage, Williams is also known for his epic standup specials, including “The Pimp Chronicles,” “It’s Pimpin’ Pimpin’,” “Katt Williams: Pimpadelic,” “American Hustle,” “Priceless: Afterlife,” “Kattpacalypse,” and the critically acclaimed “Katt Williams: Great America” on Netflix. In 2002, Williams made his onscreen debut as a guest star on “NYPD Blue.” Soon after, Williams began to consistently book television appearances, before landing his first feature film role as Money Mike in “Friday After Next.” Following his breakout performance in the sequel to “Friday,” Williams captured the attention of directors, producers, and audiences in a major way, eventually racking up an extensive list of memorable onscreen appearances including “Father Figures,” “Norbit,” “Scary Movie V,” “Epic Movie,” “Bastards,” “Cats & Dogs: The Revenge of Kitty Galore,” “The Boondocks,” “Wild 'n Out,” “The House Next Door: Meet the Blacks 2,” and his guest role in “Atlanta,” which earned him a Primetime Emmy® Award for Outstanding Guest Actor in a Comedy Series. After conquering the stage, Williams shifted his focus into film and television. By 1999, he had cultivated a loyal fan base and was performing on some of the most notable comedy stages in the nation. The Best Comedy Specials on Netflix to Watch Right Now Katt Williams Squashes Beef with Tiffany Haddish, Bows Appropriately Katt Williams Gives 1,000 to. He quickly developed a unique style of standup that highlights articulate and sharp dialogue, rooted in conversations reflecting the American political landscape. He had a role as Money Mike in Friday After Next, had a stint on Wild 'n Out, portrayed Bobby Shaw in My Wife and Kids, provided the voice of A Pimp Named. Since performing his first stand-up show as a teenager, Williams has been taking the comedy world by storm. Micah Sierra 'Katt' Williams (born September 2, 1971) is an American stand-up comedian, actor, rapper, singer, and voice actor. Filmed at Dolby Live at Park MGM in Las Vegas, “World War III” explores the subject of conspiracy theories, delivering a realistic but humorous critique of some of the most bizarre and alarmingly prevalent theories. His latest stand-up special, “Katt Williams: World War III,” premiered May 17 on Netflix. With a career spanning over 20 years, Williams has earned a worldwide reputation as one of today's top entertainers, having developed a career seeded with thousands of sold-out arenas, an expansive list of starring roles on the small screen and memorable performances in major box office hits. Specials (and other video) 2018, Katt Williams: Great America 2017, Def Comedy Jam 25 2014, Katt Williams: Priceless: Afterlife. … I’m not gonna hide in a bunker, I’m on the front line with you.”īy the end, Williams admits that his speech really wasn’t a standup routine, but says he “kept most of the jokes in quarantine if you was looking for some laughs.”Ĭheck it out in the Instagram clip above.Comedy legend and Emmy® Award-winning actor, Katt Williams is coming to Scope Arena on Saturday, September 17. ingenuity on stage, Williams is also known for his epic standup specials. That changed last week when Williams released his. ![]() “Because we can all agree breathing is important, we can all agree that you putting your knee on a man’s neck for eight minutes … It’s just murder,” he said. Comedy titan and Emmy Award-winning actor, Katt Williams, announces his World. Williams hasnt released a special since 2018, when he dropped Great America. “This isn’t the first time New York has gone through something like this, and this isn’t the first time our country has gone what it’s going through now,” Williams warned.Ī post shared by Supreme on at 7:05am PDTĪlso Read: How Comedian Bert Kreischer's Drive-In Shows Rescued His Tour From the PandemicĪnd, of course, he touched on the brutal murder of George Floyd. In 2006, Williams starred in his first flagship show, a comedy special titled Katt Williams: Live: Let a Playa Play. 'They don't even talk about the War on Drugs anymore. ![]() 'Too much shit goin' on,' Williams says on stage from Dolby LIve in Las Vegas. While most of the content is X-rated, he does zero in on the War on Drugs at the 20-minute mark. During one emotional moment, he brings up Hart Island, an area in The Bronx used as a mass grave for disease-related deaths and unclaimed bodies and which was filled with thousands of victims of the AIDS epidemic in the ’80s and ’90s. CelebStoner Katt Williams is back with a new special - his second on Netflix - called World War III. At this temple, Lord Shiva is worshipped as Kuber Bhandari. Karnali is famous for its Kuber Bhandari Temple which is said to be around 2,500 years old. It is based on the story that Lord Shiva took the form of an eagle to destroy evil forces and thereby is named as Garudeshwar. This ancient temple of Lord Shiva is situated on the Northern bank of Narmada River, near the town of Rajpipla. Garudeshwar is home to the temple of Garudeshwar Mahadev. The temple of Kashivishwanath Mahadev, the major attraction of which is its interesting wall paintings, can be visited here. The palace is a favourite location for Bhojpuri film shoots throughout the year.Ĭhanod is a city of temples located at the confluence of the Narmada, Orsang and Saraswati rivers, and is therefore considered highly sacred. ![]() It was once the centre of a princely state and famous for its palaces. Rajpipla is 36 kilometre away from the Sardar Sarovar Dam. The word ‘Shoolpaneshwar’ refers to Lord Shiva portrayed as having a ‘Shool’ or ‘Trishul’ in his hand or `Pani’. However, a new Shoolpaneshwar temple was later built near Rajpipla. The original Shoolpaneshwar Temple was submerged due to the Sardar Sarovar Reservoir. The sanctuary has the rare distinction of having flying squirrels. The sanctuary is a home to 32 species of mammals, several species of reptiles, 198 species of birds and many animals like sloth bear, leopard, rhesus macaque, common mongoose, Indian civet cat, Indian porcupine, four-horned antelope, barking deer, chital, pangolin, flying squirrel, python, snakes, lizards, tortoises, etc. There are more than 575 species of flowering plants like Timru, Amla, Khair, Aritha, Sadad, Tanachh, Karanj, Bamboo, Mahuda, Bor, Herde, Amaltas etc. The flora of the ecosystem consists of semi-evergreen to moist deciduous forest. The sanctuary derives its name ‘Shoolpaneshwar’ from the historic temple of Lord Shiva, which once existed in this region on the banks of river Narmada. ![]() The thick vegetative ground cover not only provides endless greenery but also a huge habitat to a variety of life forms. It includes a major watershed feeding two major reservoirs with the Rajpipla hills as a backdrop. Shoolpaneshwar Wildlife Sanctuary is spread over an area of 607.70 square kilometre. Annually, 11.7 billion cubic metre of water is conveyed through this canal. It is the origin of 458 kilometre long Narmada Main Canal which is one of the world’s largest concrete-lined irrigation canals with a capacity of 40,000 cubic feet/second. The Head Regulator of Main Canal is an off-taking structure and is 82.6 metres long having 5 radial gates of size 12.20 metres x 13.50 metres. The Godbole Gate releases water from the Sardar Sarovar Dam back to the river Narmada, thus sustaining the downstream eco-system. It has six Francis type reversible turbine generators with 200 MegaWatt installed capacity each. The River Bed Power House is an underground power house stationed on the right bank of the river located about 165 metres downstream of the dam. ![]() The Full Reservoir Level (FRL) of the Sardar Sarovar Dam is fixed at RL 138.68 metres (455 feet). The reservoir occupies an area of 37,000 hectares and has linear stretch of 214 kilometre of water and an average width of 1.77 kilometre. This dam, with its spillway discharging capacity of 85,000 cubic metre per second (3 million cubic foot per second), stands third in the world, Gazenba (113,000 cubic metre per second) in China and Tucurri (100,000 cubic metre per second) in Brazil being the first two. In terms of volume of concrete involved for gravity dams, this dam is ranked as the second largest in the world with an aggregate volume of 6.82 million cubic metre only after Grand Coulee Dam in the USA with a total volume of 8.0 million cubic metre being the largest. The Sardar Sarovar Dam is the third highest concrete dam (163 metres) in India after Bhakra (226 metres) in Himachal Pradesh and Lakhwar (192 metres) in Uttar Pradesh.
large and spatially proximal paratopes, minimal newly exposed SASA upon terminal trimming, and a. Binding function is evaluated against several molecular targets to determine which proteins evolve specific binding variants. This simple yet versatile model system can help elucidate the molecular interactions implicated in MLOs and pave ways to a new type of biomimetic materials. Protein scaffold libraries consisting of millions of unique variants are expressed with diversified binding interfaces. We report the structure of a Lig-E type DNA ligase bound to the nicked DNA-adenylate reaction intermediate, confirming that complete encirclement is unnecessary for substrate. Moreover, the droplets formed are capable of recruiting proteins and RNAs and providing a favorable environment for a biochemical reaction with highly enriched components, thereby mimicking the function of natural MLOs. In the present study, we have used a structure-guided mutagenesis approach to investigate the role of conserved regions in the Lig E proteins with respect to DNA binding. Hybrids undergo LLPS into micron-sized liquid droplets resembling LLPS in vitro and in living cells. ( a) The mevalonate pathway was placed under expression. There is a striking parallel with the structure of a mini-Glu-zincin, which represents the minimum structure of a Glu-zincin (a metallopeptidase in which the third zinc ligand is a glutamic acid). we have used a structure-guided mutagenesis approach to investigate the role of conserved regions in the Lig E proteins with respect to DNA binding. Figure 3: Synthetic scaffolds built from modular protein-protein interaction domains provide modular control over metabolic pathway flux. It contains the minimum structural features of a member of this protein superfamily, and can be described as a 'mini- zincin'. Here, we report the first design of synthetic hybrids consisting of short oligopeptides of fewer than 10 residues as "stickers" and dextran as a "spacer" to recapitulate the characteristics of IDPs, as exemplified by the multivalent FUS protein. DNA Binding With a Minimal Scaffold: Structure-Function Analysis of Lig E DNA Ligases Nucleic Acids Res. The advantages include smaller size and a more robust, single-domain structural framework with a defined binding surface amenable to mutation. Genetic engineering is generally applied to reconstruct IDPs harboring over 100 amino acid residues. Engineered small non-antibody protein scaffolds are a promising alternative to antibodies and are especially attractive for use in protein therapeutics and diagnostics. Liquid-liquid phase separation (LLPS) is an emerging and universal mechanism for intracellular organization, particularly, by forming membraneless organelles (MLOs) hosting intrinsically disordered proteins (IDPs) as scaffolds. |
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